منابع مشابه
Factors XI and XII as Targets for New Anticoagulants
Compared with vitamin K antagonists, the direct oral anticoagulants (DOACs) are simpler to administer and are associated with less intracranial bleeding. Nonetheless, even with the DOACs, bleeding still occurs and many patients with atrial fibrillation fail to receive anticoagulant thromboprophylaxis because of the fear of bleeding. Therefore, there is an urgent need for safer anticoagulants. R...
متن کاملContributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI.
Previous studies have suggested that human platelets can promote the activation of factor XI by two different mechanisms, one requiring factor XII and ADP-treated platelets and the other requiring collagen-treated platelets in the apparent absence of factor XII. To investigate these hypotheses. isolated platelets were tested for their capacity to promote the activation and cleavage of purified ...
متن کاملMeasured lifetimes of metastable levels of Mn X , Mn XI , Mn XII , and Mn XIII ions
An ion storage technique, based on the capture of metastable multiply charged ions from an external ion source into a Kingdon ion trap, has been used to measure the lifetimes of eight metastable levels of Mn ions with 3s3p configurations, k51 – 4. Although several lifetime calculations exist, some of the transition wavelengths have not been previously observed in any source. The lifetimes range...
متن کاملSelective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits.
Central venous catheter thrombosis can cause venous obstruction and pulmonary embolism. To determine the extent to which catheter thrombosis is triggered by the contact or extrinsic pathway of coagulation, we used antisense oligonucleotides (ASOs) to selectively knock down factor (f)XII, fXI, or high-molecular-weight kininogen (HK), key components of the contact pathway, or fVII, which is essen...
متن کاملHuman blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII.
Human blood coagulation Factor XI was purified in 20% yield from plasma by ion exchange chromatography. The specific clotting activity of purified Factor XI was 250 & 20 units/mg implying that its concentration in normal titrated human plasma is 4 pg/ml. The purified Factor XI in its precursor form gave a single protein band on polyacrylamide gels in the presence of sodium dodecyl sulfate with ...
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ژورنال
عنوان ژورنال: The Journal of the Society of Chemical Industry, Japan
سال: 1952
ISSN: 0023-2734,2185-0860
DOI: 10.1246/nikkashi1898.55.245